![]() Main Outcome Measures Serum tHcy, folate, and vitamin B 12 levels in patients and controls at entry the odds ratio of DAT or confirmed AD with elevated tHcy or low vitamin levels and the rate of disease progression in relation to tHcy levels at entry. Setting Referral population to a hospital clinic between July 1988 and April 1996. Objective To examine the association of AD with blood levels of tHcy, and its biological determinants folate and vitamin B 12.ĭesign Case-control study of 164 patients, aged 55 years or older, with a clinical diagnosis of dementia of Alzheimer type (DAT), including 76 patients with histologically confirmed AD and 108 control subjects. Since elevated plasma total homocysteine (tHcy) level is a risk factor for vascular disease, it may also be relevant to AD. Shared Decision Making and Communicationīackground Recent studies suggest that vascular disease may contribute to the cause of Alzheimer disease (AD).Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience. ![]() Challenges in Clinical Electrocardiography. ![]()
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